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Phenotypes Associated with This Genotype
Genotype
MGI:4429499
Allelic
Composition
Stat3tm1Dlv/Stat3tm1Dlv
Tg(Csf1r-icre)1Jwp/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Dlv mutation (0 available); any Stat3 mutation (70 available)
Tg(Csf1r-icre)1Jwp mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mutant mice that do not show symptoms of colitis have significantly lower body weights at older ages compared to controls
• observed after colitis develops

digestive/alimentary system
• mice with or without evident colitis show increased intestinal mucosal thickening predominantly in the proximal colon
• significant decrease in goblet cell density in inflamed colon is observed compared to controls
• visible polyps are found in inflamed areas of cecum
• herniation of colonic mucosa is observed in inflamed cecum
• mice with or without evident colitis show increased intestinal mucosal thickening predominantly in the proximal colon
• herniation of colonic mucosa is also observed in inflamed colon
• hyperplasia and dysplasia are also exhibited in inflamed intestinal tissue with over 60% of animals showing dysplasia between 8-39 weeks of age compared to no controls showing such phenotypes
• mice receiving antibiotics to reduce intestinal microflora show inhibition of inflammation in the colon and reduction in mucosal thickening compared to untreated mutants
• persistent proliferation of colonic epithelium in response to inflammation is observed compared to controls, with no difference in level of cell death
• colonic epithelial differentiation is perturbed in inflamed region
• visible polyps are found in inflamed areas of proximal colon and cecum
• most lesions are 'flat' with a broad base or are morphologically similar to 'dysplasia-associated lesions or masses'
• polyps/lesions are tumorous
• tumors develop in proximal colon and cecum
• mice receiving antibiotics to reduce intestinal microflora show inhibition of inflammation and tumor development in the colon; no tumors are detected in treated animals 21-27 weeks of age
• observed after colitis develops; animals produce bloody feces
• about 20% of animals develop pronounced colitis at 8 weeks of age; by 18-20 weeks, around 50% of animals develop colitis

immune system
• moderately increased in proximal colon in mutants
• significant increase in CD3+ T cells in proximal colon
• mutants have significantly higher density (number) of macrophages in the proximal colon
• mice have higher leukocytic infiltration scores (degree of leukocytic infiltration and increased mucosal thickness) than controls
• almost all mutants develop inflammation of the colon compared to 1 control showing increased leukocytic infiltration; leukocytic infiltration score and infiltration of macrophages and T lymphocytes are reduced in treated mutants, but infiltrated macrophage number is still much higher than in controls
• about 20% of animals develop pronounced colitis at 8 weeks of age; by 18-20 weeks, around 50% of animals develop colitis
• mice with or without evident colitis show increased leukocytic infiltration compared to controls
• mice receiving antibiotics to reduce intestinal microflora show inhibition of inflammation in the colon

hematopoietic system
• moderately increased in proximal colon in mutants
• significant increase in CD3+ T cells in proximal colon
• mutants have significantly higher density (number) of macrophages in the proximal colon

neoplasm
• tumors develop in proximal colon and cecum
• mice receiving antibiotics to reduce intestinal microflora show inhibition of inflammation and tumor development in the colon; no tumors are detected in treated animals 21-27 weeks of age
• carcinoma is identified in some polyps (nodules) with invasion to submucosa or muscularis external; about 16% of mutants develop carcinoma
• presence of irregular or angulated glands with cell loss, desmoplasia and multiple invading mucosa are also observed
• cells in invasive glands exhibit severe atypia with pleomorphism and basement membrane loss

behavior/neurological
• mutant mice that do not show symptoms of colitis are less active at older ages compared to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory