Phenotypes Associated with This Genotype

Genotype
MGI:4429479

• Allelic Composition: Ppara^tm1Gonz/Ppara^tm1Gonz
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:129848 )

• when fed a high fat diet

abnormal glucose homeostasis ( J:129848 )

• in a hyperinsulinemic-euglycemic clamp study, peripheral glucose disposal in mice fed a high fat diet is improved compared to in similarly treated wild-type mice

improved glucose tolerance ( J:129848 )

• when fed a high fat diet compared with similarly treated wild-type mice

increased insulin sensitivity ( J:129848 )

• when fed a high fat diet compared with similarly treated wild-type mice

increased skeletal muscle triglyceride level ( J:129848 )

• in the gastrocnemius when fed a high fat diet

muscle

increased muscle cell glucose uptake ( J:129848 )

• when fed a high fat diet, muscle glucose uptake is improved compared with similarly treated wild-type mice

increased skeletal muscle triglyceride level ( J:129848 )

• in the gastrocnemius when fed a high fat diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:129848 )

• when fed a high fat diet

cellular

increased muscle cell glucose uptake ( J:129848 )

• when fed a high fat diet, muscle glucose uptake is improved compared with similarly treated wild-type mice