Phenotypes Associated with This Genotype

Genotype
MGI:4429457

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: B6.BKS(D)-Lepr^db/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased body temperature ( J:166105 )

decreased carbon dioxide production ( J:166105 )

decreased oxygen consumption ( J:166105 )

impaired glucose tolerance ( J:166105 )

insulin resistance ( J:166105 )

abnormal response/metabolism to endogenous compounds ( J:166105 )

• mice treated with leptin fail to exhibit a decrease in food intake unlike similarly treated wild-type mice

behavior/neurological

abnormal behavior ( J:112820 )

• faster in food finding trials relative to controls

decreased locomotor activity ( J:166105 )

• during the dark phase

renal/urinary system

glomerulosclerosis ( J:160943 )

• homozygotes develop significant glomerulosclerosis by 18 weeks of age