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Phenotypes Associated with This Genotype
Genotype
MGI:4422186
Allelic
Composition		 Stk3tm1.1Yy/Stk3tm1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk3tm1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk4tm1.1Yy mutation (0 available); any Stk4 mutation (72 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
enlarged liver ( J:156541 )
• at 1 - 7 months after tamoxifen treatment
increased liver tumor incidence ( J:156541 )
• some mice treated with tamoxifen at birth develop cholangiocarcinomas composed of mainly multilayered biliary epithelial cells
increased hepatocellular carcinoma incidence ( J:156541 )
• all mice treated with tamoxifen at birth develop tumors which display characteristics of hepatocellular carcinoma by 6 months of age

neoplasm
increased liver tumor incidence ( J:156541 )
• some mice treated with tamoxifen at birth develop cholangiocarcinomas composed of mainly multilayered biliary epithelial cells
increased hepatocellular carcinoma incidence ( J:156541 )
• all mice treated with tamoxifen at birth develop tumors which display characteristics of hepatocellular carcinoma by 6 months of age
increased carcinoma incidence ( J:156541 )
• some mice treated with tamoxifen at birth develop cholangiocarcinomas composed of mainly multilayered biliary epithelial cells

cardiovascular system
enlarged heart ( J:156541 )
• in some mice at 1 - 7 months after tamoxifen treatment

digestive/alimentary system
enlarged stomach ( J:156541 )
• at 1 - 7 months after tamoxifen treatment

hematopoietic system
enlarged spleen ( J:156541 )
• in some mice at 1 - 7 months after tamoxifen treatment

immune system
enlarged spleen ( J:156541 )
• in some mice at 1 - 7 months after tamoxifen treatment

cellular

growth/size/body
enlarged heart ( J:156541 )
• in some mice at 1 - 7 months after tamoxifen treatment
enlarged liver ( J:156541 )
• at 1 - 7 months after tamoxifen treatment
enlarged spleen ( J:156541 )
• in some mice at 1 - 7 months after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory