Phenotypes for Stk3 Stk4 MGI:4422183 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Stk3^tm1.1Yy/Stk3^tm1Yy Stk4^tm1.1Yy/Stk4^tm1.1Yy
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3^tm1.1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk3^tm1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk4^tm1.1Yy mutation (0 available); any Stk4 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased liver tumor incidence ( J:156541 )

• at 12 months of age tumors develop in 2 of 31 mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:156541 )

• in untreated mice

increased circulating aspartate transaminase level ( J:156541 )

• in untreated mice

liver/biliary system

increased liver tumor incidence ( J:156541 )

• at 12 months of age tumors develop in 2 of 31 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23