Mouse Genome Informatics
cx
    Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm

involves: 129S6/SvEvTac * FVB/N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• whole-gut transit time (WGTT) is significantly prolonged compared to controls starting at 3 months through 12 months of age;
• motility of distal colon is reduced in males compared to controls at 6 and 12 months
• amount of stool passed/unit time and stool water content are unchanged at 3 months of age but by 6 months these parameters are reduced to comparable degrees
• at 12 months of age, changes in stool production and water content are even more marked
• reduction in stool wet weigh results from a reduction in water content and reduction in the dry mass of stool output

behavior/neurological
N
• mice show no motor abnormalities; rotarod latencies and distances traveled in open field tests are similar to controls at 6 and 12 months

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:156741