Analysis Tools
mortality/aging
|
• although present in normal Mendelian ratios at E14.5, fewer than expected live mice are born
|
|
• although present in normal Mendelian ratios at E14.5, fewer than expected live mice are born
|
hematopoietic system
| N |
• mice exhibit normal bleeding
|
|
• at 6 to 7 weeks and worsening with age in some mice
|
|
• spleen weight is more than 3 times that weight of normal spleens
|
|
• a 2-fold decrease in Ter119+ cells indicates impaired erythropoiesis
• precursor populations relative to mature cells and cell death are increased in the bone marrow and spleen indicating ineffective erythropoiesis
• fetal liver cells exhibit a delay in cell cycle maturation and maturation compared to in wild-type mice
|
|
• the number of hematopoeitic cells including Ter11+ cells is increased in the spleen compared to in wild-type mice
|
|
• mice exhibit signs of a mild compensated anemia unlike in wild-type mice
• in some mice anemia worsens with age
|
|
• the cytoplasmic to nuclear ratio is decreased compared to in wild-type cells
• however, endo-reduplication and megakaryocyte numbers are normal
|
|
• bone marrow cultured in the presence of thrompoietin for only small colonies unlike similarly treated wild-type cells
• however, in vivo exhibit a normal number of megakaryocytes
|
|
• red blood cell distribution width is increased compared to in wild-type mice
• however, mice exhibit no microcytosis and normal red blood cell count, hemoglobin concentration, and hematocrit
|
|
• 2-fold
|
|
• platelets exhibit an increase in lysosomal-like vacuoles compared with wild-type cells
|
|
• platelets exhibit a paucity of alpha-granules compared with wild-type cells
|
|
• mice exhibit macrothrombocytopenia unlike wild-type mice
(J:156393)
• platelet counts are reduced to 11% of platelet counts in wild-type mice
(J:156393)
|
|
• occasionally
|
|
• 2-fold
|
|
• reticulocyte counts are increased compared to in wild-type mice
• some anemic mice exhibit peripheral reticulocytosis unlike wild-type mice
|
|
• at E12.5
|
immune system
|
• at 6 to 7 weeks and worsening with age in some mice
|
|
• spleen weight is more than 3 times that weight of normal spleens
|
|
• 2-fold
|
|
• 2-fold
|
|
• at E12.5
|
|
• plasma levels of CXCL4, CXCL5, and CXCL7 are attenuated compared to in wild-type mice
|
cardiovascular system
|
• modest
|
homeostasis/metabolism
|
• plasma levels of CXCL4, CXCL5, and CXCL7 are attenuated compared to in wild-type mice
|
growth/size/body
|
• modest
|
|
• at 6 to 7 weeks and worsening with age in some mice
|
|
• spleen weight is more than 3 times that weight of normal spleens
|
