Analysis Tools
nervous system
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• increasing accumulation of alpha-synuclein is detected in cell bodies at 1 month compared to A53T/LRRK2WT-L animals
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astrocytosis
(
J:156512
)
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• A53T/LRRK2WT mice show significant elevation of GFAP-positive astrocytes in the striatum compared to A53T mice
• more GFAP-positive astrocytes are found in the brain than in A53T/LRRK2WT-L brains
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microgliosis
(
J:156512
)
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• increased microglial activation is observed in the brain
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• neuron loss is detected at 6 months and later
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• the Golgi complex is drastically altered in neurons at 1 month with severely fragmented cis-Golgi
• at 1 month, the medial/trans-Golgi in neurons is severely fragmented
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• neurodegeneration is accelerated in the striatum
• dramatic loss (>80%) of striatal neurons is seen in the dorsal striatum
• most degenerating neurons are striatal medium-sized spiny neurons (MSN)
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• neuropathology is accelerated in mice compared to A53T mice
• in 6 month old mice, elevated levels of ubiquitin are detected in somas and nuclei of cortical neurons; levels of alpha-synuclein and ubiquitin are slightly higher than in A53T mutant mice
• brain homogenates contain significantly elevated levels of ubiquitinated proteins at 3 months
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immune system
microgliosis
(
J:156512
)
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• increased microglial activation is observed in the brain
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hematopoietic system
microgliosis
(
J:156512
)
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• increased microglial activation is observed in the brain
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cellular
astrocytosis
(
J:156512
)
|
• A53T/LRRK2WT mice show significant elevation of GFAP-positive astrocytes in the striatum compared to A53T mice
• more GFAP-positive astrocytes are found in the brain than in A53T/LRRK2WT-L brains
|
microgliosis
(
J:156512
)
|
• increased microglial activation is observed in the brain
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