Tg(tetO-LRRK2)C7874Cai
Transgene Detail

Summary

• Symbol: Tg(tetO-LRRK2)C7874Cai
• Name: transgene insertion C7874, Huaibin Cai
• MGI ID: MGI:4420758
• Synonyms: tetO-LRRK2
• Transgene: Tg(tetO-LRRK2)C7874Cai Location: unknown
• Alliance: Tg(tetO-LRRK2)C7874Cai page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-LRRK2)C7874Cai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: A transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2 gene under the control of a tetO promoter. The construct was microinjected into C57BL/6J fertilized oocytes, and 5 independent lines were generated including line C7874. Founder mice were bred to C57BL/6J mice to establish this colony. (J:133490, J:154755, J:156512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
• All: 4 reference(s)