Phenotypes for Brca1 Trp53 MGI:4420438 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brca1^tm1Mak/Brca1^tm1Mak Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Mak mutation (0 available); any Brca1 mutation (113 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:41254 )

• mice survive until E9.5

embryo

failure of initiation of embryo turning ( J:41254 )

embryonic growth retardation ( J:41254 )

• at E9.5

decreased embryo size ( J:41254 )

• at E9.5

abnormal allantois morphology ( J:41254 )

abnormal visceral yolk sac morphology ( J:41254 )

growth/size/body

embryonic growth retardation ( J:41254 )

• at E9.5

decreased embryo size ( J:41254 )

• at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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