Phenotypes Associated with This Genotype

Genotype
MGI:4420391

• Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:122813 )

• following intracerebral hemorrhage, mice exhibit increased neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice

circling ( J:122813 )

• following intracerebral hemorrhage, mice exhibit increased circling behavior and compulsory circling compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:122813 )

• mice subjected to intracerebral hemorrhage exhibit increased infarct size, neutrophil infiltration, reactive oxygen species production, DNA damage, and neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice

• however, neuronal degeneration is not statistically different

increased cerebral infarct size ( J:122813 )

• following intracerebral hemorrhage

immune system

increased acute inflammation ( J:122813 )

• following intracerebral hemorrhage, mice exhibit increased infiltration of neutrophils at the site of injury compared with similarly treated wild-type mice

nervous system

increased susceptibility to ischemic brain injury ( J:122813 )

• mice subjected to intracerebral hemorrhage exhibit increased infarct size, neutrophil infiltration, reactive oxygen species production, DNA damage, and neurological deficits including attributes of body symmetry, circling behavior, and compulsory circling compared with similarly treated wild-type mice

• however, neuronal degeneration is not statistically different

increased cerebral infarct size ( J:122813 )

• following intracerebral hemorrhage