Phenotypes Associated with This Genotype

Genotype
MGI:4418957

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/Jcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased beta cell mass in Lepr^db/Lepr^db mice and Lepr^db/Lepr^db Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:156725 )

abnormal pancreas physiology ( J:156725 )

• at 8 weeks, pancreatic islet cell proliferation is increased compared to in heterozygous mice

• however, pancreatic islet cell proliferation by 16 weeks is normal

increased pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is increased compared to in heterozygous mice

homeostasis/metabolism

hyperglycemia ( J:156725 )

increased circulating insulin level ( J:156725 )

adipose tissue

abnormal epididymal fat pad morphology ( J:110277 )

• the epididymal fat pad exhibits macrophage infiltration unlike in wild-type mice

cellular

increased pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is increased compared to in heterozygous mice