Phenotypes Associated with This Genotype

Genotype
MGI:4418944

• Allelic Composition: Cebpb^tm2.1Acle/Cebpb^tm2.1Acle
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cell proliferation ( J:155795 )

• decreased proliferation of MEFs

hematopoietic system

abnormal osteoclast morphology ( J:155795 )

• in the tibiae osteoclast size is decreased

decreased osteoclast cell number ( J:155795 )

• in the tibiae osteoclast number is decreased

homeostasis/metabolism

increased circulating interleukin-6 level ( J:155795 )

• after partial hepatectomy, IL-6 serum levels rise higher than in wild-type

immune system

abnormal osteoclast morphology ( J:155795 )

• in the tibiae osteoclast size is decreased

decreased osteoclast cell number ( J:155795 )

• in the tibiae osteoclast number is decreased

increased circulating interleukin-6 level ( J:155795 )

• after partial hepatectomy, IL-6 serum levels rise higher than in wild-type

liver/biliary system

impaired liver regeneration ( J:155795 )

• hepatocytes enter the cell cycle later and at a lower frequency

• however, liver weight recovery is similar to controls, suggesting that enhanced hepatocyte hypertrophy compensates for the decrease in proliferation

reproductive system

reproductive system phenotype ( J:155795 )

N • unlike in mice null for all isoforms, females are fertile and have normal mammary gland development

skeleton

abnormal osteoclast morphology ( J:155795 )

• in the tibiae osteoclast size is decreased

decreased osteoclast cell number ( J:155795 )

• in the tibiae osteoclast number is decreased

increased bone volume ( J:155795 )

• increase in bone volume

increased trabecular bone thickness ( J:155795 )

• bone trabeculae are of an increased thickness