Cebpb^tm2.1Acle
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm2.1Acle
• Name: CCAAT/enhancer binding protein beta; targeted mutation 2.1, Achim Leutz
• MGI ID: MGI:4418931
• Synonyms: Cebpb^{delta uORF}
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm2.1Acle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155795
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The coding sequence was replaced with a version with a mutant initiation site, ATG to TTG, followed by a floxed neo cassette. Cre mediated recombination removed the neo cassette. This change resulted in the absence of the 20 kDA isoform (LIP) encoded for by this locus but leaves expression of the larger isoforms intact. (J:155795)

Expression

In Mice Carrying this Mutation:	104036 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

References

• Original: J:155795 Wethmar K, et al., C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals. Genes Dev. 2010 Jan 1;24(1):15-20
• All: 6 reference(s)