Phenotypes Associated with This Genotype

Genotype
MGI:4418901

• Allelic Composition: Esr1^tm1Ksk/Esr1^tm1Ksk; Esr2^tm1Unc/Esr2^tm1Unc; Inha^tm1Bay/Inha^tm1Bay
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84989 )

• most female mice die between 4 and 6 weeks of age and all die by 9 weeks of age

• male mice survival 19 weeks

reproductive system

decreased male germ cell number ( J:84989 )

♂ • male germ cells are depleted and degenerated

abnormal ovary morphology ( J:84989 )

♀ • tubule-like structures resembling Sertoli-like cells are found adjacent to tumor unlike in wild-type mice

increased ovary tumor incidence ( J:84989 )

♀ • mice develop aggressive bilateral ovarian tumors with hemorrhagic foci

♀ • tumors contain granulosa-like cells

abnormal seminiferous tubule morphology ( J:84989 )

♂ • tubule lumens are filled with Sertoli cells unlike in wild-type mice

dilated seminiferous tubule ( J:84989 )

♂

increased testis tumor incidence ( J:84989 )

♂ • mice develop testicular tumors formed of granulosa-like cells with numerous sites of hemorrhage

♂ • mice fail to develop early Sertoli cells unlike in Esr1^tm1Ksk Inha^tm1Bay or Esr2^tm1Unc Inha^tm1Bay double homozygotes

neoplasm

increased ovary tumor incidence ( J:84989 )

♀ • mice develop aggressive bilateral ovarian tumors with hemorrhagic foci

♀ • tumors contain granulosa-like cells

increased testis tumor incidence ( J:84989 )

♂ • mice develop testicular tumors formed of granulosa-like cells with numerous sites of hemorrhage

♂ • mice fail to develop early Sertoli cells unlike in Esr1^tm1Ksk Inha^tm1Bay or Esr2^tm1Unc Inha^tm1Bay double homozygotes

growth/size/body

decreased body weight ( J:84989 )

• compared with Esr1^tm1Ksk and Esr2^tm1Unc single homozygotes

cachexia ( J:84989 )

• at 26 weeks

increased body weight ( J:84989 )

• compared to in Inha^tm1Bay

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:84989 )

endocrine/exocrine glands

abnormal ovary morphology ( J:84989 )

♀ • tubule-like structures resembling Sertoli-like cells are found adjacent to tumor unlike in wild-type mice

increased ovary tumor incidence ( J:84989 )

♀ • mice develop aggressive bilateral ovarian tumors with hemorrhagic foci

♀ • tumors contain granulosa-like cells

abnormal seminiferous tubule morphology ( J:84989 )

♂ • tubule lumens are filled with Sertoli cells unlike in wild-type mice

dilated seminiferous tubule ( J:84989 )

♂

increased testis tumor incidence ( J:84989 )

♂ • mice develop testicular tumors formed of granulosa-like cells with numerous sites of hemorrhage

♂ • mice fail to develop early Sertoli cells unlike in Esr1^tm1Ksk Inha^tm1Bay or Esr2^tm1Unc Inha^tm1Bay double homozygotes

cellular

decreased male germ cell number ( J:84989 )

♂ • male germ cells are depleted and degenerated