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Phenotypes Associated with This Genotype
Genotype
MGI:4418655
Allelic
Composition
Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic
Background
B6.129P2-Ccr5tm1Kuz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Kuz mutation (2 available); any Ccr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

behavior/neurological
N
• response to kainic acid similar to controls
• become catatonic and display staring behavior within 15 minutes
• myoclonic twitching, frequent rearing and falling
• seizures lasting up to 5 hours
• female mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice
• of an ethanol, saccharin, or quinine solution
• in female but not male mice

immune system
• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice
• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

mortality/aging
N
• 40% mortality after kainic acid treatment

nervous system
N
• selective CA3 hippocampal pycnosis after kainic acid treatment as in controls
• susceptibility of cerebral granule cell neurons to kainic acid is similar to controls

vision/eye
• 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium
• 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium

cardiovascular system
• 34% less neovascularization than controls 2 weeks after denudation of corneal epithelium
• 34.9% less neovascularization than controls 4 weeks after denudation of corneal epithelium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:162707


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory