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Phenotypes Associated with This Genotype
Genotype
MGI:4418566
Allelic
Composition
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (51 available)
Tg(Camk2a-cre)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• the specific neuronal cell architecture in the striatum and the hippocampus is not altered

behavior/neurological
• almost completely lack a preference for sucrose
• do not remember their negative experience
• do not remember their negative experience
• starting around 6-8 weeks of age in an open field make fewer total arm entries in an elevated plus maze
• almost completely lack a preference for sucrose
• make more entries into and spend more time in open arms in an elevated plus maze
• slightly improved performance in some trials during standard accelerated rotarod analysis
• in a new environment
• in a new environment

growth/size/body
• almost double the body weight as compared to controls by 5-6 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Kleefstra Syndrome 610253 J:155739


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory