Analysis Tools
craniofacial
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• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
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• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
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• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
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• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
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limbs/digits/tail
polydactyly
(
J:154920
)
|
• bilateral hindlimb-specific duplication of digit IV is observed
|
digestive/alimentary system
|
• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
|
• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
|
• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
|
|
• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
|
growth/size/body
|
• mesenchymal cell proliferation is significantly increased at E12.5 in the anterior region, but not in the posterior region at this age, or in either region at E14.0
|
|
• at E13.5, palatal shelves appear smaller and have moved less down the tongue compared to wild type
• at E14.0, a significant reduction in size of the anterior region of the palatal shelves is detected with no significant changes in cell densities in the anterior or posterior aspects
|
|
• at E18.5 and 15.5, 18 of 21 embryos analyzed show a complete cleft of the secondary palate
|
|
• morphogenesis of the palatal shelves is severely retarded and comes to a premature hold with elevated palatal shelves only apparent at E14.5 in contrast to wild-type where elevated shelves are seen at E14.25 and fusion occurs between E14.5 and 15.5
|
