Phenotypes Associated with This Genotype

Genotype
MGI:4417970

• Allelic Composition: Tg(Myh6-tTA)6Smbf/0; Tg(tetO-HDAC5*)1Eno/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:81967 )

• DOX removal results in male death within 7-10 days and within about 30 days for female

behavior/neurological

lethargy ( J:81967 )

• after DOX withdrawal, males become extremely lethargic 2 days before death

decreased grooming behavior ( J:81967 )

• after DOX withdrawal, males display decreased grooming 2 days before death

hyporesponsive to tactile stimuli ( J:81967 )

• after DOX withdrawal, males become less responsive to handling 2 days before death

cardiovascular system

abnormal heart morphology ( J:81967 )

• cristae are highly disturbed with large areas of blebbing in male mice 8 days after DOX withdrawal

• mitochondria appear swollen and 60% larger in male mice 8 days after DOX withdrawal

• the lipid body increase is reversed by 8 days after DOX withdrawal

• dramatic increase in lipid bodies in heart tissue of male mice 5 days after DOX withdrawal

myocardium necrosis ( J:81967 )

• cellular necrosis in males after DOX withdrawal

abnormal cardiovascular system physiology ( J:81967 )

• expression analysis shows inhibited PGC-1alpha and metabolic enzymes after DOX withdrawal

decreased heart rate ( J:81967 )

• after DOX withdrawal, in unanesthetized males the heart rate is decreased to 230 beats per minute, compared with about 600 in normal littermates

myocarditis ( J:81967 )

• inflammation is seen in males after DOX withdrawal

immune system

myocarditis ( J:81967 )

• inflammation is seen in males after DOX withdrawal

homeostasis/metabolism

abnormal lipid level ( J:81967 )

• dramatic increase in lipid bodies in heart tissue of male mice 5 days after DOX withdrawal

• the lipid body increase is reversed by 8 days after DOX withdrawal

abnormal metabolism ( J:81967 )

• expression analysis shows inhibited PGC-1alpha and metabolic enzymes after DOX withdrawal

muscle

myocardium necrosis ( J:81967 )

• cellular necrosis in males after DOX withdrawal

cellular

myocardium necrosis ( J:81967 )

• cellular necrosis in males after DOX withdrawal