Mouse Genome Informatics
hm
    Slc1a3tm1Kta/Slc1a3tm1Kta
B6.129P2-Slc1a3tm1Kta
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
N
• despite retinal ganglion cell loss and glaucomatous-like changes, mice exhibit normal intraocular pressure (J:124191)
• at 8 months, the optic nerve is thinner than in wild-type mice
• at 8 months
• mice exhibit optic nerve degeneration with reduction of optic nerve area, degeneration of axons, and reduced axon density compared to in wild-type mice
• fewer cells are found in the retinal ganglion layer and consist of displaced amacrine cells compared to in wild-type mice
• after 2 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells
• however, treatment with menantine prevents RGC loss
• fewer cells are found in the retinal inner nuclear layer compared to in wild-type mice
• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) unlike wild-type mice
• mice exhibit impaired multifocal electroretinogram compared with wild-type mice

cellular
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells

homeostasis/metabolism
• in retinal ganglion cells cultured with hydrogen peroxide treated Muller cells

nervous system
• after 2 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells
• however, treatment with menantine prevents RGC loss
• at 8 months, the optic nerve is thinner than in wild-type mice
• at 8 months
• mice exhibit optic nerve degeneration with reduction of optic nerve area, degeneration of axons, and reduced axon density compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Glaucoma, Normal Tension, Susceptibility to 606657 J:124191