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Phenotypes Associated with This Genotype
Genotype
MGI:4417921
Allelic
Composition
Slc1a3tm1Kta/Slc1a3tm1Kta
Genetic
Background
B6.129P2-Slc1a3tm1Kta
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a3tm1Kta mutation (0 available); any Slc1a3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• despite retinal ganglion cell loss and glaucomatous-like changes, mice exhibit normal intraocular pressure
• at 8 months, the optic nerve is thinner than in wild-type mice
• at 8 months
• mice exhibit optic nerve degeneration with reduction of optic nerve area, degeneration of axons, and reduced axon density compared to in wild-type mice
• fewer cells are found in the retinal ganglion layer and consist of displaced amacrine cells compared to in wild-type mice
• after 2 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells
• however, treatment with menantine prevents RGC loss
• fewer cells are found in the retinal inner nuclear layer compared to in wild-type mice
• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) unlike wild-type mice
• mice exhibit impaired multifocal electroretinogram compared with wild-type mice

cellular
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells

homeostasis/metabolism
• in retinal ganglion cells cultured with hydrogen peroxide treated Muller cells

nervous system
• after 2 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice
• retinal ganglion cell loss is increased when retinal ganglion cells are mixed with Muller cells treated with hydrogen peroxide unlike cells mixed with similarly treated wild-type Muller cells
• however, treatment with menantine prevents RGC loss
• at 8 months, the optic nerve is thinner than in wild-type mice
• at 8 months
• mice exhibit optic nerve degeneration with reduction of optic nerve area, degeneration of axons, and reduced axon density compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Glaucoma, Normal Tension, Susceptibility to 606657 J:124191


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory