Phenotypes Associated with This Genotype

Genotype
MGI:4417913

• Allelic Composition: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Amyloid pathology and glial inflammation in hemizygous and homozygous Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain

nervous system

amyloid beta deposits ( J:155410 )

• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice

• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice

• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice

cerebral amyloid angiopathy ( J:155410 )

astrocytosis ( J:155410 )

abnormal neurite morphology ( J:155410 )

homeostasis/metabolism

amyloid beta deposits ( J:155410 )

• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice

• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice

• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice

cerebral amyloid angiopathy ( J:155410 )