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Phenotypes Associated with This Genotype
Genotype
MGI:4417912
Allelic
Composition
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit 85% survival
• 2 of 13 mice die before 12 months of age

nervous system
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age
• dense-core plaques are encompassed by a sphere of early-dystrophic, swollen neurites with ubiquitin accumulation unlike in wild-type mice

behavior/neurological
• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
• at 12 months, mice exhibit reduced performance in a Morris water maze test compared with wild-type mice
• at 12 months, mice from the cross-sectional cohort display poor memory in a Morris water maze compared with wild-type mice
• at 4 months but not in older mice, anxiety related behaviors are increased with mice spending less time in the center of an open field and entering the open sector of a zero maze compared with wild-type mice
• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
• at 4 months but not in older mice, exploratory activity is decreased in a Y maze compared with wild-type mice

immune system

hematopoietic system

homeostasis/metabolism
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:155410


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory