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Phenotypes Associated with This Genotype
Genotype
MGI:4417844
Allelic
Composition		 Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/0
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
abnormal immune system physiology ( J:155298 )
• decrease in the numbers of adoptively transferred transgenic CD8+ T cells compared to controls by 30 days after immunization

hematopoietic system
decreased NK cell number ( J:155298 )
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
decreased CD8-positive, alpha-beta T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
decreased memory T cell number ( J:155298 )
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory