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Phenotypes Associated with This Genotype
Genotype
MGI:4415714
Allelic
Composition
Fmr1tm1Rbd/Y
Genetic
Background
B6.129-Fmr1tm1Rbd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Rbd mutation (2 available); any Fmr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased exploratory behavior
• travel a greater total distance in the open field compared with their wild type littermates
• travel a greater proportion in the center of the open field
• a greater number of light-dark transitions than their wild type littermates
• no significant difference for the total time spent in the dark
• lower acoustic startle compared to their wild type littermates
• no significant difference in prepulse inhibition (PPI) responses
• increased locomotor activity
• travel a greater total distance in the open field compared with their wild type littermates
• increased repetitive/perseverative responses
• bury significantly more marbles than their wild type littermates
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076)
• increased audiogenic seizure susceptibility
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates

nervous system
• increased audiogenic seizure susceptibility
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates
• metabotropic glutamate receptor-dependent long term depression (mGluR-LTD) in hippocampal CA1 neurons is enhanced in the presence of anisomycin

integument
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076)

Mouse Models of Human Disease
OMIM ID Ref(s)
Fragile X Mental Retardation Syndrome 300624 J:155593


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory