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Phenotypes Associated with This Genotype
Genotype
MGI:4415714
Allelic
Composition
Fmr1tm1Rbd/Y
Genetic
Background
B6.129-Fmr1tm1Rbd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Rbd mutation (2 available); any Fmr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• travel a greater proportion in the center of the open field (J:155593)
• a greater number of light-dark transitions than their wild type littermates (J:155593)
• no significant difference for the total time spent in the dark (J:155593)
• travel a greater proportion in the center of the open field (J:155593)
• a greater number of light-dark transitions than their wild type littermates (J:155593)
• no significant difference for the total time spent in the dark (J:155593)
• increased exploratory behavior (J:155593)
• travel a greater total distance in the open field compared with their wild type littermates (J:155593)
• increased exploratory behavior (J:155593)
• travel a greater total distance in the open field compared with their wild type littermates (J:155593)
• lower acoustic startle compared to their wild type littermates (J:155593)
• no significant difference in prepulse inhibition (PPI) responses (J:155593)
• lower acoustic startle compared to their wild type littermates (J:155593)
• no significant difference in prepulse inhibition (PPI) responses (J:155593)
• increased locomotor activity (J:155593)
• travel a greater total distance in the open field compared with their wild type littermates (J:155593)
• increased locomotor activity (J:155593)
• travel a greater total distance in the open field compared with their wild type littermates (J:155593)
• increased repetitive/perseverative responses (J:155593)
• bury significantly more marbles than their wild type littermates (J:155593)
• increased repetitive/perseverative responses (J:155593)
• bury significantly more marbles than their wild type littermates (J:155593)
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076) (J:155593)
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076) (J:155593)
• increased audiogenic seizure susceptibility (J:155593)
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates (J:155593)
• increased audiogenic seizure susceptibility (J:155593)
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates (J:155593)

nervous system
• increased audiogenic seizure susceptibility (J:155593)
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates (J:155593)
• increased audiogenic seizure susceptibility (J:155593)
• 18% of the 2-3 month old mice have audiogenic seizures, versus none in wild-type littermates (J:155593)
• metabotropic glutamate receptor-dependent long term depression (mGluR-LTD) in hippocampal CA1 neurons is enhanced in the presence of anisomycin (J:155593)
• metabotropic glutamate receptor-dependent long term depression (mGluR-LTD) in hippocampal CA1 neurons is enhanced in the presence of anisomycin (J:155593)

integument
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076) (J:155593)
• greater latency to hindlimb response in hotplate than wild type mice (p=0.076) (J:155593)

Mouse Models of Human Disease
OMIM ID Ref(s)
Fragile X Mental Retardation Syndrome 300624 J:155593


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory