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Phenotypes Associated with This Genotype
Genotype
MGI:4415702
Allelic
Composition
Dnaic1tm1.1Leo/Dnaic1tm1.1Leo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaic1tm1.1Leo mutation (0 available); any Dnaic1 mutation (25 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (1 available); any Gt(ROSA)26Sor mutation (313 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• following treatment with tamoxifen, cultured tracheal ciliated epithelium exhibits no ciliary activity likely due to a lack of outer dynein arms unlike similarly treated wild-type samples
• however, epithelium morphology and number of ciliated cells are normal following treatment with tamoxifen
• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice
• however, no lung inflammation develops in tamoxifen-treated mice
• after 3 months, tamoxifen-treated mice exhibit absent mucociliary clearance in the nasopharynx and a 50% decreased in the trachea compared with wild-type mice
• after 6 months, 3 of 4 tamoxifen-treated mice exhibit no mucociliary clearance in the trachea while 1 of 4 mice exhibit a substantial reduction in clearance compared with similarly treated wild-type mice
• after 7.5 months, tamoxifen-treated mice exhibit no mucociliary clearance in the trachea compared with similarly treated wild-type mice

immune system
• tamoxifen-treated mice exhibit chronic rhinosinusitis unlike wild-type mice
• however, no lung inflammation develops in tamoxifen-treated mice

nervous system
N
• despite ciliary defects, tamoxifen-treated mice exhibit no evidence hydroencephaly

Mouse Models of Human Disease
OMIM ID Ref(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:155730


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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory