Phenotypes Associated with This Genotype

Genotype
MGI:4415311

• Allelic Composition: Xcl1^tm1Rakr/Xcl1^tm1Rakr; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:155297 )

• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )

• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice

decreased cytotoxic T cell cytolysis ( J:155297 )

• 12 days after immunization in adoptive transfer experiments

decreased interferon-gamma secretion ( J:155297 )

• immunized T cells produce less IFN-gamma on day 12 compared with similarly treated wild-type cells

hematopoietic system

decreased T cell number ( J:155297 )

• 12 days after immunization in an adoptive transfer experiment, the number of T cells in the spleen, lymph nodes, lung, liver, and bone marrow are reduced compared with wild-type cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:155297 )

• fewer CD8+ T cells respond to antigen-cross presentation by CD8+ dendritic cells compared to in wild-type mice

decreased cytotoxic T cell cytolysis ( J:155297 )

• 12 days after immunization in adoptive transfer experiments