Phenotypes Associated with This Genotype

Genotype
MGI:4415143

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:102845 )

• structures derived from the second arch, including the stapes, styloid process, and lesser horns of the hyoid bone, are absent and replaced by first arch-like derived structures, including duplicated incus, malleus, and tympanic bone, transformed gonial bone, and partially duplicated Meckel's cartilage, with reverse polarity

absent styloid process ( J:102845 )

abnormal Meckel's cartilage morphology ( J:102845 )

• partially duplicated

abnormal hyoid bone morphology ( J:102845 )

• the lesser horns of the hyoid bone are absent

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

absent outer ear ( J:102845 )

hearing/vestibular/ear

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

absent outer ear ( J:102845 )

duplicated tympanic ring ( J:102845 )

• duplicated tympanic bone

skeleton

abnormal craniofacial bone morphology ( J:102845 )

• structures derived from the second arch, including the stapes, styloid process, and lesser horns of the hyoid bone, are absent and replaced by first arch-like derived structures, including duplicated incus, malleus, and tympanic bone, transformed gonial bone, and partially duplicated Meckel's cartilage, with reverse polarity

absent styloid process ( J:102845 )

abnormal Meckel's cartilage morphology ( J:102845 )

• partially duplicated

abnormal hyoid bone morphology ( J:102845 )

• the lesser horns of the hyoid bone are absent

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

growth/size/body

abnormal hyoid bone morphology ( J:102845 )

• the lesser horns of the hyoid bone are absent

absent outer ear ( J:102845 )