Phenotypes for Clcn7 Tg(APOE-cre)VITew MGI:4414638 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Clcn7^tm3.1Tjj/Clcn7^tm3.1Tjj Tg(APOE-cre)VITew/0
Genetic Background	B6.Cg-Clcn7^tm3.1Tjj Tg(APOE-cre)VITew

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7^tm3.1Tjj mutation (0 available); any Clcn7 mutation (42 available)
Tg(APOE-cre)VITew mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

accumulation of giant lysosomes in kidney/renal tubule cells ( J:155176 )

abnormal lysosome physiology ( J:155176 )

• degradation of the endocytosed protein in proximal tubule cells of the kidneys is disrupted compared to in wild-type mice

renal/urinary system

accumulation of giant lysosomes in kidney/renal tubule cells ( J:155176 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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