nervous system
• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice
• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal
• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice
• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice
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• at the shortest interstimulus interval, paired-pulse facilitation is impaired compared to in similarly treated wild-type mice
• however, frequency facilitation is intact
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homeostasis/metabolism
• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice
• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal
• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice
• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice
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