Grik5^tm1Cont
Targeted Allele Detail

Summary

• Symbol: Grik5^tm1Cont
• Name: glutamate receptor, ionotropic, kainate 5 (gamma 2); targeted mutation 1, Anis Contractor
• MGI ID: MGI:2668206
• Synonyms: KA2-
• Gene: Grik5 Location: Chr7:24709274-24771771 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Grik5^tm1Cont page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing two full exons and a portion of a third, collectively encoding membrane domains I and II, were replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by immunohistochemical analysis of homozygous mutant hippocampal sections. (J:81742)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik5 Mutation: 50 strains or lines available

References

• Original: J:81742 Contractor A, et al., Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003 Jan 15;23(2):422-9
• All: 13 reference(s)