Phenotypes for H2az2 Mrgprd Ret MGI:4413446 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mrgprd^tm1Mjz/? Ret^tm1Ddg/Ret^tm1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Mrgprd^tm1Mjz mutation (2 available); any Mrgprd mutation (24 available)
Ret^tm1Ddg mutation (0 available); any Ret mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neurite morphology ( J:126484 )

• at P14, GFP+ skin neuron projections are reduced and punctate unlike in control Mrgprd^tm1Mjz Ret^tm1Ddg homozygotes

• however, central axonal projections in the thoracic spinal cord exhibit normal lamina specific innervation of peptidergic and nonpectidergic projections

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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