Phenotypes Associated with This Genotype

Genotype
MGI:4413445

• Allelic Composition: Ret^tm1Ddg/Ret^tm1Ddg; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:126484 )

• few mice survive beyond 3 weeks

digestive/alimentary system

aganglionic megacolon ( J:126484 )

• at P14

enlarged ileum ( J:126484 )

• at P14

abnormal jejunum morphology ( J:126484 )

• enlarged at P14

nervous system

abnormal neuron morphology ( J:126484 )

• at P14, non-peptidergic neurons are hypotrophic unlike in control Ret^tm1Ddg homozygotes

absent enteric neurons ( J:126484 )

• in the small intestine and colon

small dorsal root ganglion ( J:126484 )

• at P14, the dorsal root ganglia is 30% smaller than in control Ret^tm1Ddg homozygotes

behavior/neurological

weakness ( J:126484 )

• beginning at P3 mice develop progressive weakness

growth/size/body

distended abdomen ( J:126484 )

• at P3