Phenotypes Associated with This Genotype

Genotype
MGI:4412052

• Allelic Composition: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
• Genetic Background: C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

enhanced long-term potentiation ( J:165986 )

• induced by tetanic stimulation independent of age and amyloid plaque deposition

increased post-tetanic potentiation ( J:165986 )

• induced by tetanic stimulation

behavior/neurological

abnormal spatial learning ( J:154968 )

• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice

• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice

impaired coordination ( J:154968 )

• on at rotarod at 4 months

growth/size/body

increased body weight ( J:154968 )

• at 4 to 12 months

cellular

abnormal neuron differentiation ( J:165986 )

• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice

• however, proliferation of neuronal progenitors is normal

homeostasis/metabolism

amyloid beta deposits ( J:154968 )

• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice

• amyloid beta deposits worsen with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:165986