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Phenotypes Associated with This Genotype
Genotype
MGI:4412052
Allelic
Composition
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Genetic
Background
C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice
• however, proliferation of neuronal progenitors is normal
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
• induced by tetanic stimulation independent of age and amyloid plaque deposition
• induced by tetanic stimulation

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• on at rotarod at 4 months

growth/size/body
• at 4 to 12 months

cellular
• at 4 weeks, mice exhibit a decrease in the number of surviving CldU+ cells in the dentate gyrus compared with wild-type mice
• however, proliferation of neuronal progenitors is normal

homeostasis/metabolism
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:165986


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory