Phenotypes Associated with This Genotype

Genotype
MGI:4411995

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm embryos exhibit severe growth retardation and apoptosis

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153804 )

• all die around E9.5

embryo

embryo phenotype ( J:153804 )

N • embryonic and extraembryonic epithelia is intact

increased embryonic tissue cell apoptosis ( J:153804 )

• 10-fold increase in apoptotic cells in embryos, indicating a nutrition defect

embryonic growth retardation ( J:153804 )

• starting around E8.5, fully apparent by E9.5

abnormal embryonic tissue morphology ( J:153804 )

• desmosomes are smaller and partially mislocalized

homeostasis/metabolism

abnormal energy homeostasis ( J:153804 )

• expression analysis indicates a nutrient shortage exists in embryos at E9.5

• addition of exogenous glucose fails to rescue the apparent nutrient shortage

abnormal metabolism ( J:153804 )

• at E9.5 protein biosynthesis is reduced in the embryo and in the yolk sac compared to wild-type controls

cellular

increased embryonic tissue cell apoptosis ( J:153804 )

• 10-fold increase in apoptotic cells in embryos, indicating a nutrition defect

growth/size/body

embryonic growth retardation ( J:153804 )

• starting around E8.5, fully apparent by E9.5