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| Caption | Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm (KO) embryos exhibit severe growth retardation and apoptosis, resulting from reduced protein biosynthesis, but maintain tissue integrity. (A-F) Semithin sections through wild-type (WT) (A-C) and mutant (D-F) embryos were stained with H&E. Note the tissue integrity in overview sections through complete E9.5 embryo in the WT (A) and the mutant (D) mice. Higher magnifications of the visceral yolk sac (B and E) and embryonic intestine (C and F) from WT and mutant embryos at E9.5 confirmed tissue integrity. (G-J) Whole mount photographs of WT (G and I) and mutant (H and J) embryos dissected from the yolk sac at E8.5 (G and H) and E9.5 (I and J). The mutant embryos were growth retarded by about 50%. | ||||
| Copyright | This image is from Vijayaraj P, J Cell Biol 2009 Oct 19;187(2):175-84, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:153804 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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