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Phenotypes Associated with This Genotype
Genotype
MGI:4411988
Allelic
Composition		 Stk3tm1.1Jav/Stk3tm1.1Jav
Stk4Gt(AJ0315)Wtsi/Stk4+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

liver/biliary system
increased hepatocellular carcinoma incidence ( J:153945 )
• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory