Phenotypes Associated with This Genotype

Genotype
MGI:4411987

• Allelic Composition: Stk3^tm1.1Jav/Stk3⁺; Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

lethargy ( J:153945 )

• starting at 7 months of age

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 6 out of 7 asymptomatic mice at 7 months old

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

liver/biliary system

liver hyperplasia ( J:153945 )

• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 6 out of 7 asymptomatic mice at 7 months old

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

growth/size/body

liver hyperplasia ( J:153945 )

• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue