Phenotypes Associated with This Genotype

Genotype
MGI:4411986

• Allelic Composition: Stk3^tm1.1Jav/Stk3^tm1.1Jav; Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153945 )

• none survive beyond E9.5

embryo

abnormal vitelline vasculature morphology ( J:153945 )

• under-vascularized yolk sacs at E9.5

failure of initiation of embryo turning ( J:153945 )

• failure to turn by E9.5

embryonic growth retardation ( J:153945 )

• first signs of retardation evident at embryonic day 8.5 (E8.5)

decreased embryo size ( J:153945 )

• E8.5 embryos are smaller

open neural tube ( J:153945 )

• failure to close the neural tube by E9.5

pale yolk sac ( J:153945 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:153945 )

• first signs of retardation evident at embryonic day 8.5 (E8.5)

decreased embryo size ( J:153945 )

• E8.5 embryos are smaller

nervous system

open neural tube ( J:153945 )

• failure to close the neural tube by E9.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:153945 )

• under-vascularized yolk sacs at E9.5

enlarged pericardium ( J:153945 )

• at E9.5