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Phenotypes Associated with This Genotype
Genotype
MGI:4411919
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(MUC1)79.24Gend/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(MUC1)79.24Gend mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
uterus adenomyosis ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, all mice develop ovarian lesions consisting of endometrial glandular epithelium unlike un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice

immune system
increased regulatory T cell number ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice with endometriosis also exhibit an increase in spleen and regional lymph nodes T regulatory cells compared with un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice
increased IgG level ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice exhibit an increase in the anti-MUC1 IgG response compared with un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice
increased IgM level ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice exhibit an increase in MUC1-specific IgM unlike un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice and similarly treated Tg(MUC1)79.24Gend mice
decreased interferon-gamma secretion ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, T cells in the spleen and regional lymph nodes exhibit decreased IFN-gamma in response to polyclonal stimulation compared with un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice

hematopoietic system
increased regulatory T cell number ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice with endometriosis also exhibit an increase in spleen and regional lymph nodes T regulatory cells compared with un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice
increased IgG level ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice exhibit an increase in the anti-MUC1 IgG response compared with un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice
increased IgM level ( J:154046 )
• following injection of a cre adenovirus in the ovarian bursa, mice exhibit an increase in MUC1-specific IgM unlike un-injected Krastm4Tyj Tg(MUC1)79.24Gend mice and similarly treated Tg(MUC1)79.24Gend mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory