Phenotypes for Insr Tg(PAH-INSR)1Rjv MGI:4410518 MGI Mouse

postnatal lethality, complete penetrance ( J:80773 )

• most mutants die within 1 week after birth, although survival is prolonged to 8-20 days in 10% of pups compared to single Insr homozygotes

abnormal inguinal fat pad morphology ( J:80773 )

• adipose tissue in the inguinal region is underdeveloped in longer surviving pups

decreased body size ( J:80773 )

• pups surviving 8-20 days are smaller

decreased body weight ( J:80773 )

• pups surviving 8-20 days weight 40-60% less than wild-type littermates at P10 and P17, respectively

increased circulating glucose level ( J:80773 )

• pups with early diabetic ketoacidosis exhibit a 6-fold increase in serum glucose levels, however this level is less than in single Insr homozygotes

decreased liver glycogen level ( J:80773 )

• pups with early diabetic ketoacidosis exhibit extremely reduced hepatic glycogen levels

• however, pups with no ketoacidosis have almost normal glycogen levels

increased urine glucose level ( J:80773 )

• 26/240 pups exhibit glycosuria, however development is delayed by more than a week compared to single Insr homozygotes

increased triglyceride level ( J:80773 )

• pups with early diabetic ketoacidosis exhibit a 2.5-fold increase in triglyceride levels

ketoaciduria ( J:80773 )

• 26/240 pups develop ketoacidosis, although development is delayed by more than a week compared to single Insr homozygotes