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Phenotypes Associated with This Genotype
Genotype
MGI:4410330
Allelic
Composition		 Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-Spdef)1Jaw/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-rtTA)1Jaw mutation (3 available)
Tg(tetO-Spdef)1Jaw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Absence of proliferation during goblet cell hyperplasia in Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Spdef)1Jaw/0 mice

respiratory system
abnormal respiratory mucosa goblet cell morphology ( J:154639 )
• doxycycline-treated mice exhibit goblet cell differentiation without proliferation unlike similarly treated wild-type mice
increased respiratory mucosa goblet cell number ( J:121284 )
• doxycycline-treated mice exhibit hyperplasia of lung goblet cells compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory