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Phenotypes Associated with This Genotype
Genotype
MGI:4399134
Allelic
Composition		 Zap70tm2.1Weis/Zap70tm2.1Weis
Tg(DO11.10)10Dlo/?
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(DO11.10)10Dlo mutation (7 available)
Zap70tm2.1Weis mutation (1 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:154166 )
• a marked reduction in the proportion and absolute numbers of CD4 SP thymocytes, and lower percentages and lower absolute numbers of CD4+ T cells expressing the transgene in the spleens and lymph nodes

immune system
abnormal positive T cell selection ( J:154166 )
• a marked reduction in the proportion and absolute numbers of CD4 SP thymocytes, and lower percentages and lower absolute numbers of CD4+ T cells expressing the transgene in the spleens and lymph nodes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory