Analysis Tools
mortality/aging
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• in DSS-treated mice
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immune system
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• during the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice
• mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice
• TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice
• transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice
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• CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice
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• granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells
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• neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice
• neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells
• recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice
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• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice
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• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice
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• while mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice
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• mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice
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homeostasis/metabolism
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• in DSS-treated mice
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digestive/alimentary system
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• during the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice
• mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice
• TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice
• transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice
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respiratory system
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• mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice
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skeleton
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• while mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice
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hematopoietic system
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• CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice
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• granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells
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• neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice
• neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells
• recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice
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• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice
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• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice
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cellular
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• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice
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• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice
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