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Phenotypes Associated with This Genotype
Genotype
MGI:4367787
Allelic
Composition		 DlstGt1Lex/Dlst+
Tg(PRNP-APPSweInd)19959Dwst/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DlstGt1Lex mutation (0 available); any Dlst mutation (17 available)
Tg(PRNP-APPSweInd)19959Dwst mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:152550 )
• in a Morris water maze, mice swim longer and travel a greater distance before reaching the platform and spend less times in the quadrant with the hidden platform compared with wild-type mice and DlstGt1Lex heterozygotes

growth/size/body
decreased body weight ( J:152550 )

nervous system
amyloid beta deposits ( J:152550 )
• female mice exhibit an increase in hippocampal plaque number and percent area covered compared to in Tg(PRNP-APPSweInd)19959Dwst mice

homeostasis/metabolism
amyloid beta deposits ( J:152550 )
• female mice exhibit an increase in hippocampal plaque number and percent area covered compared to in Tg(PRNP-APPSweInd)19959Dwst mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory