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Tg(PRNP-APPSweInd)19959Dwst
Transgene Detail
Summary
Symbol: Tg(PRNP-APPSweInd)19959Dwst
Name: transgene insertion 19959, David Westaway
MGI ID: MGI:4367784
Synonyms: Tg19959
Transgene: Tg(PRNP-APPSweInd)19959Dwst  Location: unknown  
Alliance: Tg(PRNP-APPSweInd)19959Dwst page
Transgene
origin
Strain of Origin:  129S6/SvEvTac and FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PRNP-APPSweInd)19959Dwst expresses 1 gene
 
Mutation detailsThe transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. (J:69967)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69967 Chishti MA, et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001 Jun 15;276(24):21562-70
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory