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Phenotypes Associated with This Genotype
Genotype
MGI:4367786
Allelic
Composition
Tg(PRNP-APPSweInd)19959Dwst/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

nervous system
• at 3 months, mice exhibit cerebral plaques unlike wild-type mice (J:69967)
• mutants exhibit plaque formation, with marked amyloid beta plaques at 5 months of age, with some plaques within the CA1 pyramidal cell body layer of the hippocampus (J:177369)

homeostasis/metabolism
• mutants exhibit intraneuronal amyloid beta accumulation at early ages before the formation of plaques
• the intraneuronal amyloid beta forms fibrillar species within the CA1 region of the hippocampus
• the intraneuronal fibrillar species are found within cell bodies of pyramidal and GABAergic neurons, processes, and synaptic structures, especially postsynaptic compartments
• intraneuronal fibrillar amyloid beta species are seen in individual spines that are enlarged
• accumulation of fibrillar amyloid beta species is associated with reduction in cytoskeletal proteins
• fibrillar amyloid beta species are seen piercing the cell membrane
• at 3 months, mice exhibit cerebral plaques unlike wild-type mice (J:69967)
• mutants exhibit plaque formation, with marked amyloid beta plaques at 5 months of age, with some plaques within the CA1 pyramidal cell body layer of the hippocampus (J:177369)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:177369


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory