Mouse Genome Informatics
tg
    Tg(PRNP-APPSweInd)19959Dwst/0
involves: 129S6/SvEvTac * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size

nervous system
• at 3 months, mice exhibit cerebral plaques unlike wild-type mice (J:69967)
• mutants exhibit plaque formation, with marked amyloid beta plaques at 5 months of age, with some plaques within the CA1 pyramidal cell body layer of the hippocampus (J:177369)

homeostasis/metabolism
• mutants exhibit intraneuronal amyloid beta accumulation at early ages before the formation of plaques
• the intraneuronal amyloid beta forms fibrillar species within the CA1 region of the hippocampus
• the intraneuronal fibrillar species are found within cell bodies of pyramidal and GABAergic neurons, processes, and synaptic structures, especially postsynaptic compartments
• intraneuronal fibrillar amyloid beta species are seen in individual spines that are enlarged
• accumulation of fibrillar amyloid beta species is associated with reduction in cytoskeletal proteins
• fibrillar amyloid beta species are seen piercing the cell membrane
• at 3 months, mice exhibit cerebral plaques unlike wild-type mice (J:69967)
• mutants exhibit plaque formation, with marked amyloid beta plaques at 5 months of age, with some plaques within the CA1 pyramidal cell body layer of the hippocampus (J:177369)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:177369