Phenotypes Associated with This Genotype

Genotype
MGI:4367729

• Allelic Composition: Nos2^tm1Lau/Nos2^tm1Lau
• Genetic Background: B6;129P2-Nos2^tm1Lau/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:148923 )

• following hepatic ischemia and reperfusion compared with similarly treated wild-type mice

decreased circulating aspartate transaminase level ( J:148923 )

• following hepatic ischemia and reperfusion compared with similarly treated wild-type mice

decreased susceptibility to injury ( J:148923 )

• following hepatic ischemia and reperfusion, mice exhibit reduced liver injury with improved histology due to only mild signs of vascular changes, necrosis, and apoptosis and decreased serum alanine and aspartate transferase levels, and leukocyte (neutrophils, CD3 lymphocytes, CD4 T cells, and granulocytes) recruitment compared with similarly treated wild-type mice