Phenotypes Associated with This Genotype

Genotype
MGI:4367704

• Allelic Composition: Mmp9^tm1Tvu/Mmp9^tm1Tvu; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:141587 )

N • mice survive 31% longer than Tg(SOD1*G93A)1Gur mice

nervous system

nervous system phenotype ( J:141587 )

N • neuron loss observed in Tg(SOD1*G93A)1Gur mice is attenuated

immune system

decreased tumor necrosis factor secretion ( J:141587 )

• TNF-alpha staining is absent from neuronal cells in the spinal cord unlike in Tg(SOD1*G93A)1Gur mice