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Phenotypes Associated with This Genotype
Genotype
MGI:4367270
Allelic
Composition
RhoR3/Rhotm1Jlem
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoR3 mutation (0 available); any Rho mutation (37 available)
Rhotm1Jlem mutation (7 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• between 14 and 21 days of age, complex heterozygotes for these two alleles exhibit progressive loss of ONL nuclei of intermediate severity between that of RhoR3/+ and RhoR3 homozygous mice
• from 21 days, by which the homozygous ENU mutants entirely lack ONL nuclei, the compound heterozygotes retain approximately half as many as RhoR3/+ mice until both level out at day 35, RhoR3/+ mice with 2 rows of nuclei and the compound heterozygotes with a single row

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:153281


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory