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Phenotypes Associated with This Genotype
Genotype
MGI:4367205
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (57 available)
Tg(APPSWE)2576Kha mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• fail to show intersession habituation over 3 days of testing in an open field, unlike transgenic mice wild-type for Ldlr
• learning impairment in a Morris water maze at 10 months of age
• impairment not affected by Ldlr genotype
• at 13 months of age mice trained at 10 months of age are slower to reacquire the location of the hidden platform in a morris water maze compared to transgenic mice wild-type for Ldlr
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits
• make more entries into the open arms of an elevated plus maze on day 2 of testing
• relative to non-transgenic controls

homeostasis/metabolism
• hypercholesterolemia with the increase in the non-HDL fraction
• increase is mainly in the LDL fraction
• age dependent cerebral amyloidosis
• plaques first appear in the hippocampus and cortex at around 11 months
• progressive accumulation in the brain after 11 months
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

nervous system
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:114480


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory