Mouse Genome Informatics
cx
    Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0

involves: 129S7/SvEvBrd * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• make more entries into the open arms of an elevated plus maze on day 2 of testing
• fail to show intersession habituation over 3 days of testing in an open field, unlike transgenic mice wild-type for Ldlr
• learning impairment in a Morris water maze at 10 months of age
• impairment not affected by Ldlr genotype
• at 13 months of age mice trained at 10 months of age are slower to reacquire the location of the hidden platform in a morris water maze compared to transgenic mice wild-type for Ldlr
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits
• relative to non-transgenic controls

homeostasis/metabolism
• hypercholesterolemia with the increase in the non-HDL fraction
• increase is mainly in the LDL fraction
• age dependent cerebral amyloidosis
• plaques first appear in the hippocampus and cortex at around 11 months
• progressive accumulation in the brain after 11 months
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

nervous system
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:114480