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Phenotypes Associated with This Genotype
Genotype
MGI:4367205
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• make more entries into the open arms of an elevated plus maze on day 2 of testing (J:114480)
• make more entries into the open arms of an elevated plus maze on day 2 of testing (J:114480)
• fail to show intersession habituation over 3 days of testing in an open field, unlike transgenic mice wild-type for Ldlr (J:114480)
• fail to show intersession habituation over 3 days of testing in an open field, unlike transgenic mice wild-type for Ldlr (J:114480)
• learning impairment in a Morris water maze at 10 months of age (J:114480)
• impairment not affected by Ldlr genotype (J:114480)
• learning impairment in a Morris water maze at 10 months of age (J:114480)
• impairment not affected by Ldlr genotype (J:114480)
• at 13 months of age mice trained at 10 months of age are slower to reacquire the location of the hidden platform in a morris water maze compared to transgenic mice wild-type for Ldlr (J:114480)
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits (J:114480)
• at 13 months of age mice trained at 10 months of age are slower to reacquire the location of the hidden platform in a morris water maze compared to transgenic mice wild-type for Ldlr (J:114480)
• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits (J:114480)
• relative to non-transgenic controls (J:114480)
• relative to non-transgenic controls (J:114480)

homeostasis/metabolism
• hypercholesterolemia with the increase in the non-HDL fraction (J:114480)
• hypercholesterolemia with the increase in the non-HDL fraction (J:114480)
• increase is mainly in the LDL fraction (J:114480)
• increase is mainly in the LDL fraction (J:114480)
• age dependent cerebral amyloidosis (J:114480)
• plaques first appear in the hippocampus and cortex at around 11 months (J:114480)
• progressive accumulation in the brain after 11 months (J:114480)
• age dependent cerebral amyloidosis (J:114480)
• plaques first appear in the hippocampus and cortex at around 11 months (J:114480)
• progressive accumulation in the brain after 11 months (J:114480)
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr (J:114480)
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr (J:114480)

nervous system
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr (J:114480)
• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr (J:114480)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:114480


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory